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- W2351914908 abstract "AIM:To assess the relationship between aging and sinus node function so as to observe the age-related changes of normal sinus node function. METHODS:According to the age of the rats,21 male rats were divided into 3 groups:infant group(4 wk,n=8) adult group(18 wk,n=7) and aged group (104 wk,n=6). Intrinsic heart rate(IHR),sinus node recovery time(SNRT),correct sinus node recovery time(CSNRT) were measured after(intrinsic) pharmacologic autonomic blockade(propranolol+atropine i.v.). RESULTS:After pharmacologic autonomic blockade,the rats,CSNRT(ms) lengthened progressively with age. CSNRT in the young group,the adult group and the old group was 29±6,51±9,43±10,respectively. There was significant difference between the young group and the adult group(P0.05),the young group and the old group(P0.05),and no significant difference between the adult group and the old group (P0.05). CONCLUSION:The electrophysiological measurement index of the intrinsic sinus node function(CSNRT) lengthens with the age increasing,suggesting a senescence of the intrinsic sinus node throughout life." @default.
- W2351914908 created "2016-06-24" @default.
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- W2351914908 date "2008-01-01" @default.
- W2351914908 modified "2023-09-25" @default.
- W2351914908 title "Age-related changes of intrinsic Sinus node function of rats" @default.
- W2351914908 hasPublicationYear "2008" @default.
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