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- W2351915706 abstract "Objective: To investigate the effect of epirubicin chemotherapy on metastatic potential of breast cancer and its possible mechanisms by comparison of the biological behaviors of epirubicin pre-treatment breast cancer cells with untreated cells. Methods:Human breast cancer MCF-7 and MDA-MB-231 cells were respectively treated with epirubicin for 6 hours or kept in normal culture medium. The migration and invasion capacity of these differently treated cells were assessed by wound-healing assays and transwell assays. Real-time PCR was used to analyze the alteration of m RNA levels of metastasis associated protein 1(MTA1) in MCF-7 cells treated with epirubicin for different periods of time. Mouse 4T1 breast cancer model was established to observe the effect of epirubicin chemotherapy on the occurrence of surface lung metastases. Results: In the wound-healing assays, cells treated with epirubicin showed greater wound closure between 0 and 24 hours than untreated cells in both cell lines(P 0.05). In the transwell assays, epirubicin treated MDA-MB-231 cells showed significant increase(P 0.01) in the numbers of cells invading the Matrigel-coated membrane compared with untreated cells, but the difference in MCF-7 cells was not significant, probably due to their innate low invasive capacity. Real-time PCR showed that epirubicin treatment led to a significant increase(P 0.05) in the expression of MTA1 m RNA in MCF-7 cells. In tumor-bearing mice, more surface lung metastases were observed in treated mice than untreated ones(P 0.01). Conclusions: Epirubicin treatment can promote metastasis of breast cancer cells both in vitro and in vivo, and its stimulation of MTA1 is a possible mechanism." @default.
- W2351915706 created "2016-06-24" @default.
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- W2351915706 date "2015-01-01" @default.
- W2351915706 modified "2023-09-26" @default.
- W2351915706 title "Effect of Epirubicin Chemotherapy on Metastatic Potential of Breast Cancer" @default.
- W2351915706 hasPublicationYear "2015" @default.
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