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- W2351917763 abstract "Objective:To investigate the role of glutamine and indomethacin on apoptosis of pancreatic acinar in SAP rats and underling mechanism.Methods:one hundred and four SD rats were randomly allocated to 5 groups:glutamine group(Gln group,n=24),indomethacin group(IN group,n=24),glutamine+indomethacin group(G+I group,n=24)and SAP group(n=24).Jejunotomy was performed.Gln group received glutamine,IN group received indomethacin,G+I group received indomethacin and glutamine,SAP group received saline.All groups were subdivided into 3 groups.Eight normal rats were used as controls.At 12,24,36 hours after the induction of SAP.Eight rats in each group were sacrificed 12,24,36hours later.The apoptosis of pancreatic acinar cells was detected by TUNEL method.Results:The apoptotic rate of pancreatic acinar in normal was 2.97%.The apoptotic rate of pancreatic acinar in the four experimental groups were much higher than that in control group(P0.01),among them Gln,IN and G+I were higher than SAP(P0.01),and highest was occurred in G+I group(P0.01).Conclusion:Enteral administration of glutamine and glutamine increase the apoptotic rate of pancreatic acinar.There are synergistic effects between Gln and indomethacin." @default.
- W2351917763 created "2016-06-24" @default.
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- W2351917763 date "2008-01-01" @default.
- W2351917763 modified "2023-09-22" @default.
- W2351917763 title "The Effects of Glutamine and Indomethacin on the Apoptosis of Pancreatic Acinar in Rats with Severe Acute Pancreatitis" @default.
- W2351917763 hasPublicationYear "2008" @default.
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