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- W2351939866 abstract "OBJECTIVE:To study the effects of ACA on the apoptosis and invasion of human breast carcinoma cell line MCF-7.METHODS:The effects of ACA on the expression of Bcl-2 and Bax mRNA in MCF-7 cells were detected by RT-PCR.The expression of MMP-2 and MMP-9 were determined by immunocytochemical method.RESULTS:With the treatment of ACA(50、100、150 μmol · L-1),the expression of Bcl-2 mRNA was down-regulated while the expression of Bax mRNA was up-regulated significantly(.50、100、150 μmol · L-1)ACA decreased the expression of MMP-2 and MMP-9 in MCF-7 cells.CONCLUSION:ACA exhibits apoptosis induction,which might be related to the down-regulation of Bcl-2 mRNA and up-regulation of Bax mRNA,and ACA inhibits cellular invasion through decreasing the expression of MMP-2 and MMP-9 in MCF-7." @default.
- W2351939866 created "2016-06-24" @default.
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- W2351939866 date "2012-01-01" @default.
- W2351939866 modified "2023-09-23" @default.
- W2351939866 title "Effects of ACA on Apoptosis and Invasion of Human Breast Carcinoma Cell Line MCF-7" @default.
- W2351939866 hasPublicationYear "2012" @default.
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