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- W2351946518 abstract "Objective To investigate the effects of different doses of X-ray radiation on the expression of hTrail mRNA of glioma U251 cells which transfected Ad-Egr-hTrail.Methods Ad-Egr-hTrail was identitied by RT-PCR after amplification and transfected U251 cells,X-ray of 0,2,5,8,10,12,15,18 Gy was given 48 h after the transfection,the expression level of TrailmRNA was detected by real-time quantitative-PCR.Results The expressed level of TrailmRNA started to increase at 1hour post-irradiation,and maintained a high level from 4 hour to 8 hour.The expressed level of TrailmRNA increased with the radiation dose increasing,and rase the highest at the the point of 12Gy point,then began to descend.Conclusion Egr-1 promoter can be activated by ionizing irradiation and regulate the expression of Trail gene in vitro.The expression of Trail gene is correlated with radiation dose and time interval after irradiation." @default.
- W2351946518 created "2016-06-24" @default.
- W2351946518 creator A5042644835 @default.
- W2351946518 date "2011-01-01" @default.
- W2351946518 modified "2023-09-24" @default.
- W2351946518 title "Expression property of Ad-Egr-hTrail induced by ionizing radiation" @default.
- W2351946518 hasPublicationYear "2011" @default.
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