Matches in SemOpenAlex for { <https://semopenalex.org/work/W2351957541> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2351957541 endingPage "304" @default.
- W2351957541 startingPage "296" @default.
- W2351957541 abstract "The in vitro effects of chlorpromazine on rat cardiac papillary muscle were tested at 10(-6), 10(-5) and 10(-4) M. Mechanical parameters were determined from the contraction and relaxation phases under isotonic and isometric conditions in order to assess contraction, relaxation, contraction-relaxation coupling and load sensitivity of relaxation. The peak power output Emax was determined from the force-velocity relationship. At 10(-6) M, a slight positive inotropic effect was observed, probably related to modifications in cross-bridges kinetics. Negative inotropic effects were observed with 10(-5) and 10(-4) M chlorpromazine. At 10(-5) M, shortening of the isometric relaxation and decrease in R2 = (+dF.dt-1max)/(-dF.dt-1max) suggest that chlorpromazine also diminishes myofilament Ca++ sensitivity. Emax was increased at 10(-6) M (19 +/- 5%, P less than .05), but decreased at 10(-5) M (-28 +/- 10%, P less than .05) and 10(-4) M (-82 +/- 2%, P less than .05). Modifications in the force-velocity relationship at 10(-4) M indicated that lowering myocardial performance by chlorpromazine was associated with a low muscle efficiency from a thermoenergetic point of view. At all concentrations, chlorpromazine impaired the isotonic relaxation and load sensitivity of relaxation. At 10(-4) M, muscle contracture and slowed isometric relaxation were probably due to calcium overload. These results showed that chlorpromazine finely modulates intrinsic cardiac energetics and mechanics by acting on the sarcoplasmic reticulum, myofilament Ca++ sensitivity and cross-bridges kinetics, according to the level of load and chlorpromazine concentration used." @default.
- W2351957541 created "2016-06-24" @default.
- W2351957541 creator A5034436745 @default.
- W2351957541 creator A5051176970 @default.
- W2351957541 creator A5079794318 @default.
- W2351957541 date "1990-04-01" @default.
- W2351957541 modified "2023-09-26" @default.
- W2351957541 title "Inotropic and lusitropic effects of chlorpromazine on rat left ventricular papillary muscle." @default.
- W2351957541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2158547" @default.
- W2351957541 hasPublicationYear "1990" @default.
- W2351957541 type Work @default.
- W2351957541 sameAs 2351957541 @default.
- W2351957541 citedByCount "5" @default.
- W2351957541 crossrefType "journal-article" @default.
- W2351957541 hasAuthorship W2351957541A5034436745 @default.
- W2351957541 hasAuthorship W2351957541A5051176970 @default.
- W2351957541 hasAuthorship W2351957541A5079794318 @default.
- W2351957541 hasConcept C103486182 @default.
- W2351957541 hasConcept C126322002 @default.
- W2351957541 hasConcept C134018914 @default.
- W2351957541 hasConcept C155710745 @default.
- W2351957541 hasConcept C163415756 @default.
- W2351957541 hasConcept C174054327 @default.
- W2351957541 hasConcept C185592680 @default.
- W2351957541 hasConcept C207200792 @default.
- W2351957541 hasConcept C2777274916 @default.
- W2351957541 hasConcept C2778775820 @default.
- W2351957541 hasConcept C2778996579 @default.
- W2351957541 hasConcept C2992204568 @default.
- W2351957541 hasConcept C57900726 @default.
- W2351957541 hasConcept C68923441 @default.
- W2351957541 hasConcept C71924100 @default.
- W2351957541 hasConcept C84393581 @default.
- W2351957541 hasConceptScore W2351957541C103486182 @default.
- W2351957541 hasConceptScore W2351957541C126322002 @default.
- W2351957541 hasConceptScore W2351957541C134018914 @default.
- W2351957541 hasConceptScore W2351957541C155710745 @default.
- W2351957541 hasConceptScore W2351957541C163415756 @default.
- W2351957541 hasConceptScore W2351957541C174054327 @default.
- W2351957541 hasConceptScore W2351957541C185592680 @default.
- W2351957541 hasConceptScore W2351957541C207200792 @default.
- W2351957541 hasConceptScore W2351957541C2777274916 @default.
- W2351957541 hasConceptScore W2351957541C2778775820 @default.
- W2351957541 hasConceptScore W2351957541C2778996579 @default.
- W2351957541 hasConceptScore W2351957541C2992204568 @default.
- W2351957541 hasConceptScore W2351957541C57900726 @default.
- W2351957541 hasConceptScore W2351957541C68923441 @default.
- W2351957541 hasConceptScore W2351957541C71924100 @default.
- W2351957541 hasConceptScore W2351957541C84393581 @default.
- W2351957541 hasIssue "1" @default.
- W2351957541 hasLocation W23519575411 @default.
- W2351957541 hasOpenAccess W2351957541 @default.
- W2351957541 hasPrimaryLocation W23519575411 @default.
- W2351957541 hasRelatedWork W1964220215 @default.
- W2351957541 hasRelatedWork W1991617060 @default.
- W2351957541 hasRelatedWork W1995753284 @default.
- W2351957541 hasRelatedWork W2010205757 @default.
- W2351957541 hasRelatedWork W2014098575 @default.
- W2351957541 hasRelatedWork W2064029051 @default.
- W2351957541 hasRelatedWork W2351957541 @default.
- W2351957541 hasRelatedWork W2416888914 @default.
- W2351957541 hasRelatedWork W2081918439 @default.
- W2351957541 hasRelatedWork W2183853395 @default.
- W2351957541 hasVolume "253" @default.
- W2351957541 isParatext "false" @default.
- W2351957541 isRetracted "false" @default.
- W2351957541 magId "2351957541" @default.
- W2351957541 workType "article" @default.