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- W2351960480 abstract "Purpose: We evaluated the feasibility of extracting pure left ventricular blood pool and myocardial time activity curves (TACs) and of generating factor images from human dynamic N-13 ammonia PET usin factor analysis. The myocardial blood flow (MBF) estimates obtained with factor analysis were compare with those obtained with the user drawn region-of-interest (ROI) method. Materials and Methods: Stres and rest N-13 ammonia cardiac PET imaging was acquired for 23 min in 5 patients with coronary arte disease using GE Advance tomograph. Factor analysis generated physiological TACs and factor image using the normalized TACs from each dixel. Four steps were involved in this algorithm: (a) dat preprocessing; (b) principal component analysis; (c) oblique rotation with positivity constraints; (d) facto image computation. Area under curves and MBF estimated using the two compartment N-13 ammoni model were used to validate the accuracy of the factor analysis generated physiological TACs. The MB estimated by factor analysis was compared to the values estimated by using the ROI method. Results: MB values obtained by factor analysis were linearly correlated with MBF obtained by the ROI method (slop = 0.84, r = 0.91). Left ventricular blood pool TACs obtained by the two methods agreed well (Area und curve ratio: 1.02 (0∼1 min), 0.98 (0∼2 min), 0.86 (1∼2 min)). Conclusion: The results of this stud demonstrates that MBF can be measured accurately and noninvasively with dynamic N-13 ammonia PE imaging and factor analysis. This method is simple and accurate, and can measure MBF without bloo sampling, ROI definition or spillover correction. (Korean J Nucl Med 1999;33:316-26)" @default.
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- W2351960480 date "1999-01-01" @default.
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- W2351960480 title "Quantification of Myocardial Blood flow using Dynamic N-13 Ammonia PET and factor Analysis" @default.
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