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- W2351978668 abstract "BACKGROUND To investigate the roles of E-cadherin and β-catenin genes in metastasis and prognosis of non-small cell lung cancer. METHODS The expression of E-cadherin and β-catenin were detected in 112 non-small cell lung cancer tissues and 30 benign pulmonary lesion tissues by immunohistochemical method (LSAB method). RESULTS The expression of E-cadherin and β-catenin in lung cancer tissues was significantly lower than that in adjacent non-cancerous lung tissues and benign pulmonary tissues (P < 0.01); The expression of E-cadherin and β-catenin in lung cancer tissues with lymph node and/or distant metastasis was significantly lower than that in those without lymph node and distant metastasis (P < 0.01); The 5-year survival rate in patients with low E-cadherin expression and low β-catenin expression (6.78%) was remarkably lower than that in cases with high expression (6.78% vs 35.85% and 3.78% vs 37.29%) (P < 0.01). CONCLUSIONS Underexpressions of E-cadherin and β-catenin are very common in non-small cell lung cancer, and it may play an important role in the progression and metastasis of lung cancer. Detection of expression of E-cadherin and β-catenin in lung cancer might be helpful to predict prognosis." @default.
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- W2351978668 date "2002-08-20" @default.
- W2351978668 modified "2023-09-23" @default.
- W2351978668 title "[A study on the relationship between E-cadherin, β-catenin expression and metastasis and prognosis in non-small cell lung cancer]." @default.
- W2351978668 doi "https://doi.org/10.3779/j.issn.1009-3419.2002.04.07" @default.
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