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- W2351994166 abstract "Objective To explore mechanism of multidrug resistance in nasopharyngeal carcinoma(NPC) CNE-1 cells after X-ray irradiation.Methods The drug resistance of CNE-1 cells after X-ray irradiation to cisplatin(cDDP) was determined by MTT.The expression of multidrug resistance(mdr 1) gene was tested by RT-PCR and Western blot.Results IC50 values of cDDP in cells 2～4 weeks after irradiation were significantly higher than those before irradiation(P0.01). The expression of mdr1 mRNA and P-gp in cells after irradiation increased than those before irradiation(P0.01).Conclusions X-ray irradiation may induce the expression of mdr1 gene in CNE-1 cells,which maybe play an important role in multidrug resistance after NPC irradiation." @default.
- W2351994166 created "2016-06-24" @default.
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- W2351994166 date "2006-01-01" @default.
- W2351994166 modified "2023-09-22" @default.
- W2351994166 title "X-ray irradiation induces expressions of mdrl gene in nasopharyngeal carcinoma cells and its significance" @default.
- W2351994166 hasPublicationYear "2006" @default.
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