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- W2352003347 abstract "Objective To determine the expression of INF-γ and IL-4 produced by Th cells in peripheral blood mononuclear cells (PBMC) and lymph node in patients with active tuberculosis, and to explore the immune imbalance in tuberculosis patients. Methods 20 patients including 15 patients with active pulmonary tuberculosis and 5 patients with active lymph node tuberculosis and 15 healthy volunteers were enrolled, and the blood specimens and lymph node tissue samples were obtained to determine the expression of INF-γ and IL-4 by flow cytometry. Results Th 1 cells in peripheral blood were significantly decreased in case group compared to control group (p=0.000), but Th 2 cells not (p0.05). Between lymph node tuberculosis group and control group, there were no significant differences in Th 1 and Th 2 cells (p0.05), but there were significant differences in peripheral blood (p0.05). Conclusions Th 1/Th 2 imbalance may mediate the immunity response in tuberculosis infection, there may be close association between Th 1/Th 2 imbalance and the development of tuberculosis. Also, the decreased production of Th 1 cells may be mainly found in patients' PBMC but not in local focus, and the increase of Th 2 cells may follow with the decrease of Th 1 cells in patients' PMBC." @default.
- W2352003347 created "2016-06-24" @default.
- W2352003347 creator A5079685631 @default.
- W2352003347 date "2004-01-01" @default.
- W2352003347 modified "2023-09-26" @default.
- W2352003347 title "Th_1/Th_2 Imbalance in Patients with Tuberculosis" @default.
- W2352003347 hasPublicationYear "2004" @default.
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