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- W2352006036 abstract "Objective To explore the effect of naloxone on the expression of MDA and SOD in dog' s cerebral tissue and the morphological change of the tissue after cardiopulmonary resuscitation(CPR). Methods 18 healthy adult mongrel dogs were randomly divided into three groups (n=6). Blank group: The dogs were not induced ventricular fibrillation and their cerebral tissues were collected; Control group: The dogs were performed with standard CPR after cardiac arrest; Naloxone group: The dogs were performed with standard CPR and administered with naloxone after cardiac arrest. The cerebral tissues of the dogs in both control group and naloxone group were collected 6 hours after CPR. The levels of MDA and SOD were detected and the pathological changes of the cerebral tissues were examined. Results The level of MDA in the control group was higher than that in either the blank group (P 0.01) or the naloxone group (P 0.01),while the level of SOD in the Naloxone group was higher than that in the control group (P 0.01),but lower than that in the blank group (P 0.01). The neurons of the cerebral tissues from the control group revealed obvious damage and the damage was more severe than that of the neurons from the Naloxone group. Conclusions Naloxone can reduce the development of MDA in the cerebral tissue and increase the activity of SOD after CPR. It may relieve the reperfusion injury of the neurons by reducing the damage of the cerebral tissue." @default.
- W2352006036 created "2016-06-24" @default.
- W2352006036 creator A5035612164 @default.
- W2352006036 date "2006-01-01" @default.
- W2352006036 modified "2023-09-25" @default.
- W2352006036 title "Effect of naloxone on the expression of oxygen free radical in dog′s cerebral tissue after experimental cardiopulmonary resuscitation" @default.
- W2352006036 hasPublicationYear "2006" @default.
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