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- W2352014554 abstract "AIM:To study the cardiac and heratic toxicities and the antitumor activity of doxorubicin(DR) proliposome(PL).METHODS:The activity of enzymes and the histopathological lesions of the tissues were observed to study the toxicities of DRPL and DR, while the survival rate of mice with tumor was recorded to evaluate their antitumor activity. The animals were devided into DRPL or DR groups. The toxicities and the antitumor activity of them were compared at the doses of 2.00, 1.40, 0.98 mg·kg 1 and 4, 2, 1 mg·kg 1 ,respectively.RESULTS:Compared with DRPL, DR significantly increased the activities of LDH,CK,GPT and GOT in serum of rats. DRPL significantly reduced the lesions in heart. With the same dose, DRPL could prolong the survival time of mice with EAC,Heps of ascitic more significantly than DR. CONCLUSION:The cardiac and hepatic toxicities of DRPL were much less serious than those of DR. DRPL not only remained but also significantly strengthened the antitumor activity of DR." @default.
- W2352014554 created "2016-06-24" @default.
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- W2352014554 date "1999-01-01" @default.
- W2352014554 modified "2023-09-24" @default.
- W2352014554 title "The effect of doxorubicin proliposome on toxicity of liver and heart in rats and experimental tumour" @default.
- W2352014554 hasPublicationYear "1999" @default.
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