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- W2352024774 abstract "Objective To investigate the effects,the feasibility and the mechanism of exogenous VEGF on vascular regeneration and reconstruction of the splenic tissues during the process of splenic autotransplantation into the greater omentum.Methods A total of 216 healthy Kunming mice were randomized into splenic tissue autotransplantation+VEGF group(named as VEGF group),splenic tissue autotransplantation group(control group) and sham operation group.The mice in VEGF group were injected with exogenous VEGF into the caudal veins on day 7,15,30,60 respectively after operation.Three mice of 3 groups were killed and the splenic tissue was taken as specimen on day 7,14,30,60,90 after injection of exogenous VEGF to conduct the following investigations.The morphologic changes in autotransplanted splenic tissue were observed under light microscope and electron microscope.After intubation was conducted through left ventricle and right atria was opened and lavaged with Chinese ink,the splenic tissue pieces were made and the area density of blood vessel was tested by using computer image system.The density of KDR positive cells was tested by immunohistochemical methods and computer image analysis.The expression of KDR mRNA were investigated and analyzed by in situ hybridization to study exogenous VEGF on KDR mRNA expression.Results On day 7,15,30 after injection with exogenous VEGF,the mice in VEGF group were found more renascent blood vessels,splenic corpuscles,central arteries and peripheral lymphatic sheathes in the autotransplanted splenic tissues than the control group,and eventually formed more integral structure of white pulp,marginal zone and red pulp with much less fibrous tissue,while on day 60 there was no significant difference between VEGF group and the control group.On day 7,15,30 after injection,the renascent blood vessels were more in number,the KDR area density and the KDR mRNA expression in splenic tissues were higher in VEGF group than the control group,while on day 60 there were no significant differences in the area density of renascent blood vessel,the KDR area density and the KDR mRNA expression between the two groups.Conclusion The exogenous VEGF can enhance the vascular regeneration and reconstruction of the autotransplanted splenic tissues into the greater omentum.The day 7 to day 15 after the autotransplantation of splenic tissues was the ideal period for the venous injection of exogenous VEGF that can make its effects through elevating the expression of KDR mRNA." @default.
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- W2352024774 date "2006-01-01" @default.
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- W2352024774 title "Effects of exogenous VEGF on vascular regeneration in autotransplanted splenic tissues of mice" @default.
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