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- W2352025498 abstract "Objective To investigate the relationship between the expression of ERCC1 and RRM1 in non-small cell lung cancer(NSCLC) and clinical prognosis.Methods Expression levels of ERCC1 and RRM1 in 91 NSLCL cases were detected by the Envision method.Results The total positive expression rate for ERCC1 and RRM1 was 45.05%(41/91) and 70.33%(64/91),respectively,which was significantly higher than that in adjacent normal lung tissues(P0.05).The expression and expression levels of ERCC1 and RRM1 were not correlated with the age,sex,tumor size,histological type,histological grading,lymph node metastases and clinical stages(P0.05).In clinical Stage I,the survival rate of patients with positive expression of ERCC1 and RRM1 was higher than that of those with negative expression.In the other stages,the survival rate of patients with positive expression of ERCC1 was lower than that of those with negative expression,but that of those with positive RRM1 expression was higher than that of those with negative RRM1 expression.Conclusion The expression of ERCC1 and RRM1 in NSCLC tissues is a prognostic index for individual chemotherapy,which is independent of clinical pathology." @default.
- W2352025498 created "2016-06-24" @default.
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- W2352025498 date "2011-01-01" @default.
- W2352025498 modified "2023-09-23" @default.
- W2352025498 title "Expression of ERCC1 and RRM1 in Non-Small Cell Lung Cancer (NSCLC) and Clinical Prognosis" @default.
- W2352025498 hasPublicationYear "2011" @default.
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