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- W2352035490 abstract "Objective To investigate the protective effect and its mechanisms of methylene blue (MB) on pulmonary injury after ischemia reperfusion (I/R),and the mechanism of MB. Methods Twenty four rabbits were randomly divided into three groups:sham operated group (group S) underwent an identical laparotomy except for the superior mesenteric artery (SMA) occlusion. The I/R group and MB treated group was produced by occluding the SMA for 1 hr,reperfusing for 2hrs respectively. MB group was received 1% MB by 10mg/kg before immediately removed the clip,I/R group was administered with saline. The model of intestinal I/R was developed by occluding the SMA. The serum IL-8,TNF-α concentration,the level of MDA,the activities of SOD,XOD,CAT and O2-in lung tissue were determined at the end of the experiment. Results The mean artary pressure (MAP) was significantly lower in I/R group than that in MB group after intestinal I-R (P0.01),but MAP did not significantly change in MB group. The level of O-2 and MDA in the lung tissue were markedly increased in I-R group than that of in the S group (P0.01),but no significant change in MB group. The activities of SOD and XOD in lung tissue did not significantly change in all groups. The serum concentration of IL-8 and TNF-α were significantly higher in group I/R than that in group S (P0.01),but no significant change in MB group compared to group S. The serum concentration of IL-8 and TNF-α were significantly lower in MB group than that in I-R group (P0.01). Conclusion MB can reduce lung injury after intestinal I-R. The mechanisms may be associated with inhibiting the generation of OFR and decreasing inflammatory response." @default.
- W2352035490 created "2016-06-24" @default.
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- W2352035490 date "2009-01-01" @default.
- W2352035490 modified "2023-09-26" @default.
- W2352035490 title "Methylene blue prevents lung injury after intestinal ischemia reperfusion in rabbit" @default.
- W2352035490 hasPublicationYear "2009" @default.
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