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- W2352044124 abstract "AIM:To study the pathogenesis of glomerulosclerosis in vitro and find a treatment method of glomerulosclerosis.METHODS:Human glomerular mesangial cells were purified and cultured: Low density lipoprotein(LDL) and high density lipoprotein (HDL) labelled with [ 125 I]; and human mesangial cells (HMC) proliferation measured by counting thymidine incorporation. RESULTS:(1) Cultured HMC uptake [ 125 I]LDL selectively, (2)LDL stimulated HMC proliferation and had a biphasic effect on HMC proliferation, (3)Cordyceps militaris had a strong inhibition on HMC proliferation induced by LDL. CONCLUSIONS: HMC proliferation induced by LDL may directly participate in the pathogenesis of glomerulosclerosis. The deleterious effects of hyperlipidemia on the kidney may be mediated by HMC. Therefore, inhibiting HMC proliferation may be practicable in the treatment of progressive glomerulosclerosis." @default.
- W2352044124 created "2016-06-24" @default.
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- W2352044124 date "1999-01-01" @default.
- W2352044124 modified "2023-09-24" @default.
- W2352044124 title "Proliferation of cultured human mesangial cells caused by LDL and the adserse effect of Cordyceps" @default.
- W2352044124 hasPublicationYear "1999" @default.
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