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- W2352061036 abstract "This paper studied the effects of andrographis on male mice sperm,enzyme activity and organizational structure of testis,and discussed its dosing-effect relationship.The experiment were divided into seven groups(n=25,every group): control group,andrographolide(315 mg/kg),andrographis extraction(A 75.35 g/kg,B 34.88g/kg,C 16.15g/kg,D 7.48g/kg,E 3.46g/kg),by oral gavage and administrate 1 time each day,continued for 77days(11 weeks).Tested mice were killed on the 3,5,7,9,11 weeks of administration.The weights of tested mice,hoden and nebenhoden were measured,sperm count and sperm deformity rate were detected.The testis pathological were prepared,at the same time,the activities of lactate dehydrogenase(LDH) and alkaline phosphatase(AKP) of testis were also measured.Compared with the control group,relative weight of testis and epididymis decreased significantly(P0.05);sperm count was significantly lower than the control group,and in the same period of administration,the dose was higher,the degree of reduction was more significant.Compared with the control group,sperm deformity rate was higher(P0.05,P0.01),and in the same period of administration,the dose was higher,the degree of increase was more significant.Testis homogenate LDH,AKP activity was significantly decreased compared with the control group(P0.05,P0.01),and in the same period of administration,dosage was proportional to the degree of reduction.Seminiferous tubules wall of mice testes was thin and mature sperms within the lumen was lost.Andrographis extraction and andrographolide have reproductive toxicity effects on male mice,and its toxicity exist has certain dosing-effect relationship." @default.
- W2352061036 created "2016-06-24" @default.
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- W2352061036 date "2013-01-01" @default.
- W2352061036 modified "2023-09-22" @default.
- W2352061036 title "Research on relationship between dosing and effect of andrographis reproductive toxicity" @default.
- W2352061036 hasPublicationYear "2013" @default.
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