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- W2352070804 abstract "Influence of muscarinic acetylcholine receptor(mAChR) antagonists on negative inotropic effects of tetrandrine(Tet) was studied. In isolated guinea pig left atrium, atropine(0.03 μmol·L -1 ) and AF DX 116(1 μmol·L -1 ) markedly inhibited Tet decreasing contracting force, EC 50 (μmol·L -1 ) value was changed from 28.9±0.9 to 125±21 and 127±13 respectively. Atropine (0.03 μmol·L -1 ) partially antagonized shortening effects of Tet on APD 20 and APD 50 in rabbit right atrium, but did not affect prolongation of APD 90 in high concentration of Tet. Using whole cell patch clamp to record L type calcium current (I Ca L ) and inwardly rectifier potassium current (I K1 ) in single isolated ventricle cells of guinea pig, it was found that the inhibitory effect of Tet (30 μmol·L -1 ) on I Ca L was partially antagonized by atropine (1 μmol·L -1 ). The inhibitory effect of Tet (30 μmol·L -1 ) on I K1 was not affected by atropine (1 μmol·L -1 ), while reversed by acetylcholine (1 μmol·L -1 ). The results suggest that modulation of mAChR antagonists on calcium channel blocking effects of Tet is its main ionic mechanism in attenuating negative effects of Tet." @default.
- W2352070804 created "2016-06-24" @default.
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- W2352070804 date "1999-01-01" @default.
- W2352070804 modified "2023-09-25" @default.
- W2352070804 title "Modulation by muscarinic receptor antagonists on negative inotropic effect of tetrandrine and its ionic mechanism 1" @default.
- W2352070804 hasPublicationYear "1999" @default.
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