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- W2352091299 abstract "[Objective] To explore an apoptosis of CBRH-7919 cells induced by INF in vitro and its expression of BAX.[Method] The cells line CBRH-7919 was treated with interferon(IFN) with different concentrations at different time,its morphological change was observed under microscopy.The DNA ladder of cell apoptosis was detected by agarose gel electrophoresis.The expression changes of BAX genes were detected by immunohistochemical method under interferon(IFN) treatment with different concentrations at different time.[Result] After IFN treatment,the typical apoptosis was characterized by a decrease in cell volume,condensation nuclei,chromatin condensation,nuclear fragmentation,chromatin fragmentation,formation of apoptotic bodies,etc.The result of agarose gel electrophoresis showed that typical DNA LADDER appeared with the increasing interferon concentrations.The expression of BAX gene increased obviously in 48 hour.[Conclusion] IFN could induce the apoptosis of CBRH-7919 cells,which might be resulted from the reason that IFN upregulated the expression of BAX genes and enhanced its role in the apoptosis of hepatoma cells." @default.
- W2352091299 created "2016-06-24" @default.
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- W2352091299 date "2012-01-01" @default.
- W2352091299 modified "2023-09-28" @default.
- W2352091299 title "Experimental Study on Apoptosis of Hepatoma Cells Induced by Interferon through Up-regulating Expression of BAX Protein" @default.
- W2352091299 hasPublicationYear "2012" @default.
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