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- W2352099744 abstract "Objective To investigate the expression and the effect of nuclear factor-κB(NF-κB) in neonatal sepsis.Methods We separated 77 newborn infants into 3 groups, which were septic group (26 cases),non-septic group (31 cases) and control group (20 cases). NF-κB existed in PBMC was detected in 3 different periods, including at admission, after the 24th hour and 48th hour of admission, of the septic group and the non-septic group by flow cytometry. At the same time, the sample of the septic group and the non-septic group were drawn for blood cultures at admission before using antibiotics.Results The expression of NF-κB in septic group was more significant than that in the other 2 groups (P0.01).And there was no significant difference between the non-septic group and control group.Moreover,the expression of NF-κB,in septic group,increased at admission and decreased after the 24th hour,but it was no difference between the 24th hour and 48th hour.And,the expression of NF-κB was also no significant difference at the 3 different periods in non-septic group.Conclusions It has been demonstrated that NF-κB increased in early period of neonatal sepsis, and not only can be used as a monitor standard in the early diagnosis of neonatal sepsis,but also can direct the therapy.Furthermore, the flow cytometry used in the NF-κB detecting, which considered as a sensitive and convenient method, can easily be used in most hospitals." @default.
- W2352099744 created "2016-06-24" @default.
- W2352099744 creator A5054868980 @default.
- W2352099744 date "2005-01-01" @default.
- W2352099744 modified "2023-09-23" @default.
- W2352099744 title "Value of Nuclear Factor-κB for Early Diagnosis on Neonatal Sepsis" @default.
- W2352099744 hasPublicationYear "2005" @default.
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