Matches in SemOpenAlex for { <https://semopenalex.org/work/W2352110669> ?p ?o ?g. }
- W2352110669 endingPage "199" @default.
- W2352110669 startingPage "199" @default.
- W2352110669 abstract "Since the discovery of the Hedgehog (Hh) pathway in drosophila melanogaster, our knowledge of the role of Hh in embryonic development, inflammation, and cancerogenesis in humans has dramatically increased over the last decades. This is the case especially concerning the pancreas, however, real therapeutic breakthroughs are missing until now. In general, Hh signaling is essential for pancreatic organogenesis, development, and tissue maturation. In the case of acute pancreatitis, Hh has a protective role, whereas in chronic pancreatitis, Hh interacts with pancreatic stellate cells, leading to destructive parenchym fibrosis and atrophy, as well as to irregular tissue remodeling with potency of initiating cancerogenesis. In vitro and in situ analysis of Hh in pancreatic cancer revealed that the Hh pathway participates in the development of pancreatic precursor lesions and ductal adenocarcinoma including critical interactions with the tumor microenvironment. The application of specific inhibitors of components of the Hh pathway is currently subject of ongoing clinical trials (phases 1 and 2). Furthermore, a combination of Hh pathway inhibitors and established chemotherapeutic drugs could also represent a promising therapeutic approach. In this review, we give a structured survey of the role of the Hh pathway in pancreatic development, pancreatitis, pancreatic carcinogenesis and pancreatic cancer as well as an overview of current clinical trials concerning Hh pathway inhibitors and pancreas cancer." @default.
- W2352110669 created "2016-06-24" @default.
- W2352110669 creator A5010743128 @default.
- W2352110669 creator A5017882922 @default.
- W2352110669 creator A5023411290 @default.
- W2352110669 creator A5041956982 @default.
- W2352110669 creator A5047684764 @default.
- W2352110669 creator A5059196549 @default.
- W2352110669 creator A5063751473 @default.
- W2352110669 creator A5086183279 @default.
- W2352110669 date "2016-01-01" @default.
- W2352110669 modified "2023-09-25" @default.
- W2352110669 title "Differential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date review" @default.
- W2352110669 cites W1584555042 @default.
- W2352110669 cites W1830287761 @default.
- W2352110669 cites W1950976312 @default.
- W2352110669 cites W1966583687 @default.
- W2352110669 cites W1970539851 @default.
- W2352110669 cites W1971298987 @default.
- W2352110669 cites W1974096832 @default.
- W2352110669 cites W1976109148 @default.
- W2352110669 cites W1978148663 @default.
- W2352110669 cites W1979538859 @default.
- W2352110669 cites W1984999562 @default.
- W2352110669 cites W1991111399 @default.
- W2352110669 cites W1991251040 @default.
- W2352110669 cites W1992995822 @default.
- W2352110669 cites W1996118998 @default.
- W2352110669 cites W1998029460 @default.
- W2352110669 cites W1998201418 @default.
- W2352110669 cites W2000572318 @default.
- W2352110669 cites W2002249795 @default.
- W2352110669 cites W2002355858 @default.
- W2352110669 cites W2004915038 @default.
- W2352110669 cites W2005688198 @default.
- W2352110669 cites W2011387381 @default.
- W2352110669 cites W2011649365 @default.
- W2352110669 cites W2012586673 @default.
- W2352110669 cites W2018159884 @default.
- W2352110669 cites W2018569307 @default.
- W2352110669 cites W2019214567 @default.
- W2352110669 cites W2019264784 @default.
- W2352110669 cites W2019655637 @default.
- W2352110669 cites W2021766591 @default.
- W2352110669 cites W2022430355 @default.
- W2352110669 cites W2023554450 @default.
- W2352110669 cites W2025055344 @default.
- W2352110669 cites W2025242282 @default.
- W2352110669 cites W2029443168 @default.
- W2352110669 cites W2030199762 @default.
- W2352110669 cites W2036614929 @default.
- W2352110669 cites W2039238855 @default.
- W2352110669 cites W2040935952 @default.
- W2352110669 cites W2042220638 @default.
- W2352110669 cites W2045042058 @default.
- W2352110669 cites W2046400554 @default.
- W2352110669 cites W2047269960 @default.
- W2352110669 cites W2049023072 @default.
- W2352110669 cites W2050569781 @default.
- W2352110669 cites W2051432136 @default.
- W2352110669 cites W2051550435 @default.
- W2352110669 cites W2053463048 @default.
- W2352110669 cites W2060189731 @default.
- W2352110669 cites W2061425601 @default.
- W2352110669 cites W2062114641 @default.
- W2352110669 cites W2062366556 @default.
- W2352110669 cites W2066135299 @default.
- W2352110669 cites W2067161401 @default.
- W2352110669 cites W2069439733 @default.
- W2352110669 cites W2071502249 @default.
- W2352110669 cites W2079067257 @default.
- W2352110669 cites W2080343832 @default.
- W2352110669 cites W2080416825 @default.
- W2352110669 cites W2081170157 @default.
- W2352110669 cites W2083904574 @default.
- W2352110669 cites W2084424168 @default.
- W2352110669 cites W2085786848 @default.
- W2352110669 cites W2088736923 @default.
- W2352110669 cites W2089267117 @default.
- W2352110669 cites W2091684557 @default.
- W2352110669 cites W2092536825 @default.
- W2352110669 cites W2094123668 @default.
- W2352110669 cites W2094237576 @default.
- W2352110669 cites W2097544430 @default.
- W2352110669 cites W2100562940 @default.
- W2352110669 cites W2107441200 @default.
- W2352110669 cites W2110321605 @default.
- W2352110669 cites W2112813549 @default.
- W2352110669 cites W2116247768 @default.
- W2352110669 cites W2116291955 @default.
- W2352110669 cites W2121134199 @default.
- W2352110669 cites W2121548063 @default.
- W2352110669 cites W2125923072 @default.
- W2352110669 cites W2128801071 @default.
- W2352110669 cites W2128843378 @default.
- W2352110669 cites W2131170195 @default.
- W2352110669 cites W2134116694 @default.
- W2352110669 cites W2137341140 @default.