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- W2352128210 abstract "Objective To investigate the immunophenotypic modulation of MRD detected by flow cytometry in the course of treatment with the relationship of prognosis with the level of MRDe and the time of the appearance of MRD.Methods From 2001 to 2006,63 patients with B-ALL which occurred with MRD were enrolled.These patients were detected MRD by flow cytometry and PCR.Results 1)These were 23 patients with bone marrow relapse,1 patient with the leukemia in the central nerve system,1 patient died with severe infection,32 patients followed up were disease-free.2)A total of 147 positive results were detected by flow cytometry;78 results had the modulation of immunophenotype;33 results had one membrane antigen changed;22 results had two membrane antigens changed;23 results had three or more membrane antigens changed.The changes of fluorescent intensity of CD10,CD45,CD34 were most frequent.3)Eight of 10 patients had the immunophenotypic modulation at the time of relapse.4)Patients with MRD at the levels of 10-3 had significantly lower disease-free survival compared with patients with MRD at the levels of 10-3.5)Patients with positive results in the course of maintenance treatment or end of therapy had significantly lower disease-free survival compared with patients with positive results in the treatment of consolidation.Conclusion The immunophenotype of MRD of childhood B-ALL may change during the chemotherapy.We should take this into consideration during the detection.If the MRD appears in the course of maintenance treatment or end of therapy,we may take measures immediately." @default.
- W2352128210 created "2016-06-24" @default.
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- W2352128210 date "2008-01-01" @default.
- W2352128210 modified "2023-09-27" @default.
- W2352128210 title "Analysis of immunophenotypic modulation in childhood B-ALL with positive minimal residual disease and the clinical analysis of prognosis" @default.
- W2352128210 hasPublicationYear "2008" @default.
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