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- W2352135656 abstract "IFN-γ(15μg/L)was added to PMA differentiated THP-1cells infected with M.bovis-BJ at different dose of MOI(10∶1,20∶1),the percentage of apoptotic cells was analyzed by flow cytometry at 12,24,36,48and 72h post infection.The results showed that IFN-γ promoted apoptosis of THP-1cells infected with M.bovisin a time-dependent manner.No significant statistical difference was found between the apoptotic cells infected with MOI 10∶1 and 20∶1(P0.05).THP-1cells were incubated 36hafter being treated with IFN-γ and M.bovis-BJ(MOI,10∶1). An immunocytochemistry assay was conducted to detect the presence of AIF in THP-1cells.Anti-AIF D-20 polyclonal antibodies staining demonstrated AIF translocation to the nucleus for(11.38±1.00)%and(23.26±1.85)% of THP-1cells infected with M.bovis-BJ and THP-1cells treated with IFN-γ and M.bovis-BJ,respectively.There was a significant difference(P0.05)of AIF translocation to the nucleus in PMA differentiated THP-1 cells in the presence or absence of IFN-γ,indicating that AIF signal pathway was activated in the apoptosis of M.bovis-BJ infec-ted-THP-1cells stimulated with IFN-γ.In this study,the activation of AIF signal pathway has never been reported before during the course of apoptosis of THP-1cells treated with IFN-γand M.bovis,which will contribute to eluci-date the mechanism by which IFN-γcould inhibit M.bovis in the macrophage." @default.
- W2352135656 created "2016-06-24" @default.
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- W2352135656 date "2010-01-01" @default.
- W2352135656 modified "2023-09-25" @default.
- W2352135656 title "AIF signal pathway involved in IFN-γ-promoted apoptosis of THP-1 cells during early infection with Mycobacterium bovis" @default.
- W2352135656 hasPublicationYear "2010" @default.
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