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- W2352139484 abstract "Objective To observe the influence of Candida albicans infection on T cell subsets in mice with spleen deficiency,so as to explore the immune mechanism. Methods Totally 150 healthy SPF mice were randomly divided into four groups:control group(N1 group,n = 30);Candida albicans infection group(N2,n = 40),spleen deficiency model group(M1,n = 40),spleen deficiency model combined with Candida albicans infection group(M2,n = 40). N2 and M1 mice were infected by Candida albicans at a concentration of 2×108CFU/m L. Ten mice were randomly selected from each group at 7,14,and 21 days after infection respectively,and the index was detected. Flow cytometry was used to detect the percentage of CD4+/CD8+T cells in intestinal mucosa of mice,and the expression level of IL-4 and IFN-γ m RNA was detected by RT-PCR assay. The levels of IFN-γ and IL-4 were detected by Western blot assay. Results Compared with N1 group,the proportion of CD4+T cells in the lamina of the natural layer of the small intestine was decreased(P 0.01),the proportion of CD8+T cells was increased(P 0.01),the ratio of the two was significantly decreased(P 0.01),and the expression levels of IL-4,m RNA IFN-γ and protein in the small intestine tissues were increased in other groups(P 0.01). In addition,the expression level of IFN-γ was significantly increased in M2 group,while the expression of IL-4 was significantly increased in N2 group. Conclusion The susceptibility of Candida albicans infection was increased in spleen deficiency mice,which may be closely related to the regulation of Th1/Th2 balance." @default.
- W2352139484 created "2016-06-24" @default.
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- W2352139484 date "2015-01-01" @default.
- W2352139484 modified "2023-09-26" @default.
- W2352139484 title "Influence of Candida albicans Infection on T Cell Subsets in the Mice with Spleen Deficiency" @default.
- W2352139484 hasPublicationYear "2015" @default.
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