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- W2352142802 abstract "Objective:To understand the epidemiological characteristics of cervical human papillomavirus(HPV)infection among healthy women in Gansu,explore the relationship between types of HPV and pathological grades.Methods:576 cases receiving cervical HPV typing and detection in gynecology outpatient department in the hospital from May to August in 2009 were selected,HPV typing of cervical exfoliated cells was performed by nucleic acid molecular rapid diversion hybridization gene chip technology;colposcopy,cervical multi-point biopsy and cervical canal diagnostic curettage were used in the study,pathological diagnosis was gold standard.Results:The positive rate of HPV was 19.44%,the proportion of high risk HPV was 73.21%;the detection rates of common HPV subtypes in different cervical lesions were listed as follows from high to low(detection rate10.0%):HPV16(26.12%),HPV58(15.67%)and HPV52(10.45%);cervical lesions of different pathological grades had different HPV types:HPV16,18,31 in cervical carcinoma,HPV16,58,31,33,66 in CIN Ⅱ and CIN Ⅲ,HPV16,58,52,33,39,6,11,68,cp8304 in CIN Ⅰ;for the cases with pathological diagnosis≥CIN Ⅱ,the sensitivity,specificity,positive predictive value and negative predictive value of HPV typing and detection were 79.31%,87.26%,41.07% and 97.41%,respectively.Conclusion:HPV gene typing and detection can detect various subtypes once,understanding geographic difference of distribution of HPV subtypes has directive significance for developing specific HPV vaccine suitable for the women in Gansu,which is helpful for grading,typing of cervical lesions and individual treatment." @default.
- W2352142802 created "2016-06-24" @default.
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- W2352142802 date "2010-01-01" @default.
- W2352142802 modified "2023-09-26" @default.
- W2352142802 title "Epidemiological characteristics of cervical human papillomavirus infection among women in Gansu" @default.
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