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- W2352152938 abstract "Objective To investigate the preventive and therapeutical effects of rmOP-1 on kidneys with ischemia-reperfusion injury. Methods Thirty Wistar rat models of renal ischemia-reperfusion were randomly divided into three groups: preventive group,therapeutic group and control group.The first two groups were administered with rmOP-1,250 μg/kg bw,through the superior mesenteric vein.An equal-quantity normal saline was given to the control group.BUN and Cr were measured and renal histology assessed with modified Miller's scoring. Results The difference between preventive and therapeutic groups was not significant in terms of serum BUN and Cr and Miller's scoring(F=17.47-78.15,q=1.05-2.50,P0.05),but was markedly lower than that of the control group(t= 4.39-11.18,P0.01).Histology showed that rmOP-1 decreased the renal tubule cell necrosis. Conclusion rmOP-1 can effectively protect the function and structure of kidneys with ischemia-reperfusion injury,which provides a theoretical basis for clinical application." @default.
- W2352152938 created "2016-06-24" @default.
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- W2352152938 date "2005-01-01" @default.
- W2352152938 modified "2023-09-26" @default.
- W2352152938 title "PREVENTIVE AND THERAPEUTICAL EFFECTS OF rmOP-1 ON RENAL ISCHEMIA-REPERFUSION INJURY" @default.
- W2352152938 hasPublicationYear "2005" @default.
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