Matches in SemOpenAlex for { <https://semopenalex.org/work/W2352172976> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2352172976 abstract "Objective To explore the relationship between genetic polymorphism of CYP2E1,MPO,NQO1,GSTT1,GSTM1 and susceptibility to benzene poisoning(BP).Methods The genotypes of CYP2E1,MPO,NQO1,GSTT1,GSTM1 for 100 patients with benzene poisoning and 90 workers exposed to benzene who were engaged in the same working time and job title as patients with benzene poisoning were detected by PCR-RFLP and multi-PCR.Results There was a 2.82-fold(95% CI:1.42～5.58,P0.05) increased risk of BP in the subjects with NQO1 C609T mutation genotype(T/T) compared with those carrying heterozygous(C/T) and wild type(C/C),and there was a 2.94-fold(95%CI:1.25～6.90,P0.05) increased risk of BP in the subjects with NQO1 C609T mutation genotype(T/T) compared with those carrying wild type(C/C).The subjects with GSTT1 null genotype had a 1.91-fold(95%CI:1.05～3.45,P0.05) increased risk of BP compared with those with GSTT1 non-null genotype.Three genes interaction showed that there was a 20.41-fold(95%CI:3.79～111.11,P0.01) increased risk of BP in subjects with NQO1 C609T mutation genotype(T/T) and GSTT1 null genotype and GSTM1 null genotype compared with those carrying NQO1 C609T heterozygous(C/T) and wild type(C/C) and GSTT1 non-null genotype and GSTM1 non-null genotype.Conclusion The interaction of multi-genes may be an important role to BP.The genetic polymorphisms of 3 genes(NQO1,GSTT1 and GSTM1) leaded to declining of ability of detoxifying in benzene metabolism,so the individual with NQO1 C609T mutation genotype(T/T),GSTT1 null genotype and GSTM1 null genotype is the most susceptive to benzene.It could be suggested as a biomarker to assessment the risk of benzene poisoning for individual." @default.
- W2352172976 created "2016-06-24" @default.
- W2352172976 creator A5038297423 @default.
- W2352172976 date "2007-01-01" @default.
- W2352172976 modified "2023-09-26" @default.
- W2352172976 title "Genetic polymorphisms involved in toxicant-metabolizing enzymes and susceptibility to benzene poisoning" @default.
- W2352172976 hasPublicationYear "2007" @default.
- W2352172976 type Work @default.
- W2352172976 sameAs 2352172976 @default.
- W2352172976 citedByCount "0" @default.
- W2352172976 crossrefType "journal-article" @default.
- W2352172976 hasAuthorship W2352172976A5038297423 @default.
- W2352172976 hasConcept C104317684 @default.
- W2352172976 hasConcept C126322002 @default.
- W2352172976 hasConcept C135763542 @default.
- W2352172976 hasConcept C149737253 @default.
- W2352172976 hasConcept C153911025 @default.
- W2352172976 hasConcept C33664856 @default.
- W2352172976 hasConcept C501734568 @default.
- W2352172976 hasConcept C54355233 @default.
- W2352172976 hasConcept C71924100 @default.
- W2352172976 hasConcept C86803240 @default.
- W2352172976 hasConceptScore W2352172976C104317684 @default.
- W2352172976 hasConceptScore W2352172976C126322002 @default.
- W2352172976 hasConceptScore W2352172976C135763542 @default.
- W2352172976 hasConceptScore W2352172976C149737253 @default.
- W2352172976 hasConceptScore W2352172976C153911025 @default.
- W2352172976 hasConceptScore W2352172976C33664856 @default.
- W2352172976 hasConceptScore W2352172976C501734568 @default.
- W2352172976 hasConceptScore W2352172976C54355233 @default.
- W2352172976 hasConceptScore W2352172976C71924100 @default.
- W2352172976 hasConceptScore W2352172976C86803240 @default.
- W2352172976 hasLocation W23521729761 @default.
- W2352172976 hasOpenAccess W2352172976 @default.
- W2352172976 hasPrimaryLocation W23521729761 @default.
- W2352172976 hasRelatedWork W1563777131 @default.
- W2352172976 hasRelatedWork W1994681305 @default.
- W2352172976 hasRelatedWork W2001733695 @default.
- W2352172976 hasRelatedWork W2054430383 @default.
- W2352172976 hasRelatedWork W2078721639 @default.
- W2352172976 hasRelatedWork W2084698235 @default.
- W2352172976 hasRelatedWork W2148380647 @default.
- W2352172976 hasRelatedWork W2150543950 @default.
- W2352172976 hasRelatedWork W2334904362 @default.
- W2352172976 hasRelatedWork W2354482810 @default.
- W2352172976 hasRelatedWork W2383308792 @default.
- W2352172976 hasRelatedWork W2405203155 @default.
- W2352172976 hasRelatedWork W2410508583 @default.
- W2352172976 hasRelatedWork W2577459435 @default.
- W2352172976 hasRelatedWork W2767669143 @default.
- W2352172976 hasRelatedWork W2783653539 @default.
- W2352172976 hasRelatedWork W2979723652 @default.
- W2352172976 hasRelatedWork W3030236130 @default.
- W2352172976 hasRelatedWork W3145192430 @default.
- W2352172976 hasRelatedWork W3147859166 @default.
- W2352172976 isParatext "false" @default.
- W2352172976 isRetracted "false" @default.
- W2352172976 magId "2352172976" @default.
- W2352172976 workType "article" @default.