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- W2352188049 abstract "Objective To determine whether octreotide (OCT) can induce apoptosis of implanted liver cancer cells in rat model. Methods A total of 48 male Wistar rats weighing 180-220 g were randomized into 3 groups of OCT-12h group, OCT-72h group and control group with 16 in each. All rats had the left lobe of liver resected. Walker-256 tumor was implanted and SS intraperitoneally administered at 50 μg/kg into rats in the former groups. Flow cytometry was used to determine whether OCT can induce apoptosis of transplanted tumor cells in the 1st and 2nd week. Results The apoptotic rate of implanted tumor cells was significantly higher in the former 2 groups than in the control (P0.01) in the 1st and 2nd week. However, the apoptotic rate was markedly higher in OCT-12h group than in OCT-72h group in the 1st week (P0.01). This difference disappeared in the 2nd week (P05). Conclusions OCT can induce apoptosis of implanted tumor cells in the rat model. Meanwhile, its inducing effect is time-dependent in the early stage." @default.
- W2352188049 created "2016-06-24" @default.
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- W2352188049 date "2004-01-01" @default.
- W2352188049 modified "2023-09-24" @default.
- W2352188049 title "Apoptosis of implanted liver cancer cells induced by octreotide after partial hepatectomy in rats" @default.
- W2352188049 hasPublicationYear "2004" @default.
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