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- W2352202003 abstract "Hantaviruses cause two types of human diseases: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Different hantaviruses show different degrees of virulence in humans. In Asia, the most severe cases of HFRS are due to infection with Hantaan virus (HTNV), whereas Seoul virus(SEOV) to be is considered to be mild-pathogenic to humans, causing slight symptoms. Gastric mucosa in patients with acute HFRS appeared obvious damages, including hemorrhage like squamous shape, engorgement, oedema, ulcer, and mucosa desquamation.Hantaviruses infect human endothelial cells causing little or no damage to the infected endothelium. We established primary cultures of gastric epithelial cells derived from human gastric tissue specimen in conventional culture dishes. and comparatively analyzed the growth of HTNV and SEOV in human gastric epithelial cells (HGECs) and Vero E6 cells. The results of experiments indicated that HTNV and SEOV could infect human gastric epithelial cells, which resulted in CPE. Moreover, HTNV showed a stronger promotion for apoptosis and necrosis in HGECs in vitro than SEOV. Our findings imply that HGEC is a prime target for virus infection. Hantaviruses elicit an apoptotic programme and induce CPE, which play a pivotal role in gastric mucosa damages in patients with acute HFRS." @default.
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- W2352202003 date "2006-01-01" @default.
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- W2352202003 title "Hantaviruses trigger cytopathic effect and apoptosis in human gastric epithelial cell in vitro" @default.
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