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- W2352205670 abstract "Objective To study the feasibility of conjugating lactosaminated human serum albumin and liposomes as a carrier for drugs targeted at the liver. Methods Lactosaminated human serum albumin was covalently coupled with liposomes, using biofunctional reagent N- succinimidyl- S-acetylthioacetate. Labeled with 131I, the conjugate was injected into rat tail vein to ob- serve its accumulation in the liver and the inhibitory effect of pre-injected lactosaminated albumin on the accumulation. The inhibitory effects of the conjugate- and liposome-encapsulated interferon-a on hepatitis B virus (HBV) replication were observed and compared in 2.2. 15 cells treated with the 2 preparations. Results The accumulation of the conjugate in the rat liver was twice as much as in the spleen (P0.01), and 4 to 9 times as in other organs (P0.01). Pre-injection of lactosaminated albumin did not affect the accumulation of the conjugate in the liver and spleen (P0.05). When encapsulated by the conjugate, interferon-a showed enhanced inhibitory effect on HBV replication compared with that of liposome-encapsulated interferon-a (0.01P0.05) and free interferon-a (P0.05), and to achieve similar inhibitory effect, the dosage of conjugate- encapsulated interferon-a was only l/4 and l/8 of that required by the latter 2 respectively. Conclusion The conjugate of lactosaminated albumin and liposomes is targeted at the liver guided by asialoglycoprotein receptor, and has the potential for application as a carrier for drugs targeted at the liver." @default.
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- W2352205670 date "2001-01-01" @default.
- W2352205670 modified "2023-09-23" @default.
- W2352205670 title "Study of lactosaminated liposome and its hepatotropic targeting in rats" @default.
- W2352205670 hasPublicationYear "2001" @default.
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