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- W2352206882 abstract "AIM: To investigate the effect of extracellular heat-shock protein 70(HSP70) /HSP70-peptide complexes(HSP70-PCs) on epithelial-mesenchymal transition(EMT) of human hepatocellular carcinoma HepG2 cells and its probable mechanism.METHODS: HepG2 cells were divided into 3 groups: control group,HSP70 / HSP70-PCs(2 mg / L) group and LY294002 + HSP70 / HSP70-PCs group.The mRNA and protein expression of epithelial cell surface marker E-cadherin,mesenchymal cell surface marker α-smooth muscle actin(α-SMA),phosphatidylinositol 3-kinase(PI3K) and hypoxia-inducible factor 1α(HIF-1α) was examined by real-time RT-PCR and Western blotting.RESULTS: Extracellular HSP70 /HSP70-PCs promoted the initiation of EMT of HepG2 cells.The expression of HIF-1α and PI3K significantly increased in the process of EMT of HepG2 cells.After PI3K was blocked by LY294002,EMT did not occur and HIF-1α was not up-regulated in HepG2 cells.CONCLUSION: Extracellular HSP70 / HSP70-PCs may promote EMT of hepatocellular carcinoma cells via PI3K / HIF-1α signaling pathway." @default.
- W2352206882 created "2016-06-24" @default.
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- W2352206882 date "2013-01-01" @default.
- W2352206882 modified "2023-09-24" @default.
- W2352206882 title "Effect of extracellular HSP70 /HSP70-PCs on epithelial-mesenchymal transition of human hepatocellular carcinoma HepG2 cells" @default.
- W2352206882 hasPublicationYear "2013" @default.
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