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- W2352220744 abstract "Objective to investigate the expression and the clinical significance of in non-small cell lung cancer(NSCLC).Methods the expression of α-tubulin in 91 cases of NSCLC paraffin specimens were assessed by immunohistochemistry using tissue microarray technique,and the correlations with clinicopathologic findings and survival were statistically analyzed.Results the α-tubulin is widely expressed in the patients ≤55 years is significantly higher than that in patients 55 years(χ2=6.267,P=0.012),cytoplasm of NSCLC tissues with a over expression rate of 38.46%(35/91);the over expression were shown significantly higher in stage Ⅰ and Ⅱ than in stage Ⅲ(χ2=4.280,P=0.039) and squamous cancer than in adenocarcinoma(χ2=4.067,P=0.044).However,there is no significant relationship between the expression level of α-tubulin and gender,smoking history,the tumor size or the stage of lymphatic metastasis(P0.05).There is no significant difference in prognosis between the patients with over expression of α-tubulin and the patients with lower exprssion of α-tubulin as a whole,whereas the survival of the patients ≤55 years with over expression of α-tubulin or patients with squamous carcinoma is significantly better than that of lower expression cases.Conclusion the α-tubulin is widely expressed in NSCLC and the over expression of α-tubulin is significantly correlated with the age,tumor staging and pathological type as well as the clinical prognosis of patients." @default.
- W2352220744 created "2016-06-24" @default.
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- W2352220744 date "2012-01-01" @default.
- W2352220744 modified "2023-09-22" @default.
- W2352220744 title "The expression of α-tubulin and clinical significance in NSCLC" @default.
- W2352220744 hasPublicationYear "2012" @default.
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