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- W2352230695 abstract "Objective To evaluate changes in Syndecan-1 expression during the development of human colorectal cancer.Correlation between tumour expression of Syndecan-1 and clinicopathological characteristics of patients with colorectal carcioma was studied.Methods 58 human colorectal cancer patients,12 of colorectal adenoma and 9 normal colorectal epithelium were studied,the expression of Syndecan-1 were examined by immunohistochemical method.Results Histologically,normal mucosa shows strong membranous and cytoplasmic staining of Syndecan-1,while the poorly differentiated adenocarcinoma shows a significant reduction in the expression of Syndecan-1 than that of well and moderately differentiated adenocarcinoma(P=0.003,P=0.001).Clinically,the inidence of metastasis to distant place in patients with Syndecan-1-negative tumors was significantly high(t=2.23,P=0.03).When analyzed for prognostic significance,patients with Syndecan-1-positive cancer showed a better prognosis than those with Syndecan-1-negative cancer(P=0.0104),and a multivariate Cox proportional hazard model identified reduced Syndecan-1 expression as an independent predictive factor for overall survival(P=0.001).Conclusion Our results suggest that the reduction of Syndecan-1 expression in colorectal cancer cell is closely related to the invasive character of colorectal cancer.The evaluation of Syndecan-1 expression in colorectal cancer may allow prediction of patients′survival after surgery." @default.
- W2352230695 created "2016-06-24" @default.
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- W2352230695 date "2010-01-01" @default.
- W2352230695 modified "2023-09-23" @default.
- W2352230695 title "Expression of Syndecan-1 in human colorectal cancer and the correlation with the clinicopathologic characteristice." @default.
- W2352230695 hasPublicationYear "2010" @default.
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