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- W2352251018 abstract "AIM: To investigate the variation in transmural dispersion of repolarization and its effect on T-wave in ECG in vivo . METHODS:With the monophasic action potential(MAP) recording technique,MAPs of epicardium,midmyocardium and endocardium were recorded by specially designed plung-needle electrodes at the left ventricular myocardium in 14 open -chest rabbits. After intravenous injection of dl-sotalol and ATX-II respectively,variation in transmural dispersion of repolarization on three myocardial layers and T-wave in ECG were investigated. RESULTS: ① dl-sotalol caused a preferential prolongation of the Mid-cell repolarization time (RT, 202±19 ms to 395±34 ms),giving rise to broad and sometimes low amplitiude bifurcated T waves, and increased TDR(11±4 ms to 75±25 ms) and QT interval(208±16 ms to 397±33 ms); ②ATX-II caused preferential prolongation of the Mid-cell RT(370±34 ms to 395±34 ms),a marked delay in the onset of the T waves, a sharp rise in TDR(40±21 ms to 62±19 ms) and QT interval 372±33 ms to 479±33 ms). CONCLUSION: The variation in transmural dispersion of repolarization of ventricular myocardium has important effects on the T wave of ECG in vivo of the rabbit." @default.
- W2352251018 created "2016-06-24" @default.
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- W2352251018 date "2003-01-01" @default.
- W2352251018 modified "2023-09-25" @default.
- W2352251018 title "The research of the variation in transmural dispersion of repolarization and its effect on T-wave in ECG in vivo" @default.
- W2352251018 hasPublicationYear "2003" @default.
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