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- W2352259923 abstract "Objective To investigate the effects of ginsenoside Rg1 on the expressions of matrix metalloproteinase-2 and matrix metalloproteinases-9 (MMP-2 and MMP-9) after focal cerebral ischemia-reperfusion in rats.Methods A total of 60 healthy male SD rats were randomly allocated to sham-operation,model,nimodipine,and ginsenoside Rg1 10,20,and 40 mg/kg groups (n=10 in each group). A model of middle cerebral artery occlusion (MCAO) for 2 hours was induced by suture method. Ginsenoside Rg1 (10,20,and 40 mg/kg) and nimodipine (dissolved in 1.5 mL isotonic saline) were injected intraperitoneally every morning from 5 days before the procedure to the day of the procedure in the 4 medication groups,and 1.5 mL isotonic saline was injected at the same time point once a day in the other groups. Neurological deficit scores were evaluated at 24 hours after reperfusion; the expressions of MMP-2 and MMP-9 in hippocampal area were analyzed by immunohistochemistry and Western blot.Results ①Neurological deficit scores in the sham-operation,model,nimodipine,ginsenoside Rg1 10,20,and 40 mg/kg groups were 0,2.80±0.92,1.50±0.71,2.10±0.88,1.50±0.71,and 1.30±1.06,respectively. There were significant differences (P0.05). There were significant differences between the ginsenoside Rg1 10,20 and 40 mg/kg groups and the model group (P0.05). There were no significant differences between ginsenoside Rg1 10,20 and 40 mg/kg groups and the nimodipine group (P0.05). ②The results of immunohistochemistry showed that there were expression of MMP-2 and MMP-9 in all groups,but only a few expressions in the sham-operation group,the maximum expressions was occurred in the model group. The results of Western blot showed that the expressions of MMP-2 and MMP-9 were reduced in the ginsenoside Rg1 10,20 and 40 mg/kg groups and the nimodipine group as compared with the model group,and there were significant differences (P0.05). The expressions of MMP2 and MMP-9 in the ginsenoside Rg1 10 mg/kg group were increased significantly as compared with the nimodipine group,and the 40 mg/kg group were decreased significantly (P0.05),while there was no significant difference in the 20 mg/kg group (P0.05).Conclusion The mechanism of ginsenoside Rg1 in the prevention and treatment of cerebral ischemia-reperfusion injury in rats may be associated with the inhibition of the expressions of MMP-2 and MMP-9,and the high-dose is more effective." @default.
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- W2352259923 date "2009-01-01" @default.
- W2352259923 modified "2023-09-24" @default.
- W2352259923 title "Effects of ginsenoside Rg1 on the expressions of matrix metalloproteinase-2 and-9 after focal cerebral ischemia-reperfusion in rats" @default.
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