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- W2352278599 abstract "Objective To study effect and mechanism of Compound Biejia Ruangan Prescription(CBRP) on preventing injury of free radical in pulmonary fibrosis rats.Methods SD male rats were randomly divided into seven groups(ten rats in each group) as normal group,Sham group,model group,prednisone group,and CBRP(1.4,0.7,0.35 g/kg) groups.Rats were injected with bleomycin A5 by trachea to establish pulmonary fibrosis rat model and rats were given drugs by ig in all groups.Activities of SOD,GSH-Px,and iNOS,and MDA level in pulmonary tissues of different groups were measured.Expression of NF-κB and IκBα in protein of pulmonary tissues was studied by means of Western blotting also.Results CBRP can raise activities of GSH-Px and SOD and lessen MDA level and iNOS activity.It can also downregulate the expression of NF-κB and upregulate the expression of IκBα.Conclusion CBRP can regulate the level of free radical in pulmonary fibrosis rats and lessen the oxidative injury of pulmonary tissues caused by free radical in pulmonary fibrosis rats.The mechanisms of CBRP on pulmonary fibrosis lie in adjusting the activity of NF-κB and further moderate that of IκBα." @default.
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- W2352278599 date "2005-01-01" @default.
- W2352278599 modified "2023-09-26" @default.
- W2352278599 title "Effect of Compound Biejia Ruangan Prescription on preventing injury of free radical in pulmonary fibrosis rats" @default.
- W2352278599 hasPublicationYear "2005" @default.
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