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- W2352280108 abstract "Background and purpose:Autologous peripheral blood stem-cell transplantation (APBSCT) is a main treatment for patients with malignant lymphoma (ML). The conditioning regimen is considerable, but safe and effective conditioning regimens are necessary for APBSCT. We retrospectively evaluated the treatment and effect of BEAM conditioning regimens for patients with ml undergoing APBSCT. Methods:22 patients with ml received APBSCT. 17 patients received conditioning regimens of BEAM:BCNU 300 mg/m2·d-1×1 d(—6 d),VP16 200 mg/m2·d-1×4 d(—5 d to —2 d), cytarabine 400 mg/m2·d-1×4 d(—5 d to —2 d), melphalan 140 mg/m2·d-1×1 d(—1 d). 5 patients received conditioning regimens of BEAM combined with idarubicin (20-40 mg) to strengthen effectiveness. Results:Except for 1 case who died in multiple organ failure before re-establishment of haematogenesis, all patients were successfully engrafted. The time of ANC≥0.5×109/L and PLT≥20×109/L were at(11.4±4.4) and(15.6±3.8)d, respectively. With a median follow-up of 433 days (range, 7-1 410) 13 patients with complete remission are alive. The estimated 2-year overall survival (OS) and disease free survival (DFS) were (68.2±3.3)% and (59.1±3.2)%, respectively. The OS of the patients with complete remission and incomplete remission (partial remission, relapse, progression of disease) pretransplant were (91.6±3.1)% and(40.2±4.2)%, and DFS were(91.1±4.2)% and(20.2±4.6)% ,respectively(P0.001). Conclusions:The treatment of BEAM conditioning regimens for patients with ml undergoing APBSCT is safe and effective . The success ratio of APBSCT depends on the status of complete remission pretransplant." @default.
- W2352280108 created "2016-06-24" @default.
- W2352280108 creator A5047043019 @default.
- W2352280108 date "2008-01-01" @default.
- W2352280108 modified "2023-09-25" @default.
- W2352280108 title "The treatment of BEAM conditioning regimens for patients with malignant lymphoma undergoing autologous peripheral blood stem-cell transplantation" @default.
- W2352280108 hasPublicationYear "2008" @default.
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