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- W2352289488 abstract "OBJECTIVE To explore the function and chromosome location of differentially expressed Genes between primary nasopharyngeal carcinoma and chronic nasopharyngitis tissue. METHODS Affymetrix Gene 1.0 ST gene chip was used to examine the differentially expressed genes between primary nasopharyngeal carcinoma tissues and chronic nasopharyngitis tissues. Their chromosome location and function was characterized by bioinformatics. RESULTS A difference in expression levels of more than 3 times were found in 102 genes. Of them,25 genes were up-regulated and 77 genes were down-regulated. Except for 5 genes with unknown localization,the remaining 97 differentially expressed genes are sporadically located. However,chromosome 1 contained the most differentially expressed genes,followed by chromosomes 3. When these genes were classified according to their functions,they were found that most of them belonged to the enzymes group,followed by protein binding group,immunization genes and calciumion genes. These made up 65.6% of all the differentially expressed genes. CONCLUSION Differentially expressed genes in pNPC seemed to be sporadically distributed across the genome,but most were found on chromosomes 1,3. Four groups associated genes abnormality played an important role in the early stage of primary nasopharyngeal carcinoma." @default.
- W2352289488 created "2016-06-24" @default.
- W2352289488 creator A5035040618 @default.
- W2352289488 date "2010-01-01" @default.
- W2352289488 modified "2023-09-28" @default.
- W2352289488 title "Function and chromosome location of differentially expressed genes in primary nasopharyngeal carcinoma" @default.
- W2352289488 hasPublicationYear "2010" @default.
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