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- W2352296927 abstract "Objective To observe the dynamic of cellular immune response in spleen and gut-associated lymphoid tissue(GALT)of mice induced by intranasal immunization with Toxoplasma gondii RH strain excreted-secreted antigen(ESA)extracted from the co-culture of tachyzoites and Vero cells.Methods Divide 84 BALB/c mice into test and control groups randomly and immunize twice by intranasal drip,at an interval of 2 weeks,with 20 μg of ESA and 20 μg of Vero cell culture supernatant containing no tachyzoites respectively.Kill a part of the mice 1,2,3,4,5,6 and 7 weeks after the 2nd immunization respectively for counting of lymphocytes in spleens and Peyer patches(PP)as well as intestinal intraepithelial lymphocytes(IEL).Results The spleen lymphocyte counts of mice in test group reached a peak value 3 weeks,and were significantly higher than those in control group 1-3 weeks after the 2nd immunization.The counts of lymphocytes in PP of mice in test group reached a peak value 3 weeks,and were significantly higher than those in control group 1-5 weeks after the 2nd immunization.However,the IEL counts of mice in test group reached a peak value 2 weeks,and were significantly higher than those in control groups 1-3 weeks after the 2nd immunization.Conclusion Mucosal and systemic cellular immune responses were induced effectively and persistently by intranasal immunization with ESA of Toxoplasma gondii RH strain in mice." @default.
- W2352296927 created "2016-06-24" @default.
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- W2352296927 date "2007-01-01" @default.
- W2352296927 modified "2023-09-23" @default.
- W2352296927 title "Dynamic of Cellular Immune Response of Spleen and Gut-associated Lymphoid Tissue Induced by Intranasal Immunization with Toxoplasma gondii Excreted-secreted Antigens in Mice" @default.
- W2352296927 hasPublicationYear "2007" @default.
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