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- W2352303229 abstract "Objective To observe the synthesis of Toll like receptor (TLR) 4 protein and its mRNA expression in Kupffer cells (KCs) and evaluate the role of TLR 4 and Cytokines in the liver injury in the rats with alcohol induced liver disease(ALD).Methods Twenty and eight Wistar rats were divided into two groups: ethanol fed group (group E) and control group (group C). Group E were fed ethanol(dose of 5～12g.kg -1 .d -1 ) and group C received dextrose instead of ethanol. Rats of the two groups were sacrificed at 4 wk and 8 wk. KCs were isolated . TLR 4 mRNA in KCs was determined by the reverse transcription polymerase chain reaction (RT PCR) analysis. The levels of tumor necrosis factor (TNF) α and interleukin (IL) 6 in plasma were determined with enzyme linked immunsorbent assay (ELISA). Results Ethanol administration led to a significant increase in TLR 4 mRNA expression compared with group C (P0.01). The concentrations of TNF αand IL 6 were (326±42 )ng/L, (402±51) ng/L, (387±46) ng/L and (413±51)ng/L, respectively,in group E which were higher than that in group C (86±12 )ng/L,(97±13)ng/L, (73±10 ) ng/L and(78±11) ng/L at 4 wk and 8 wk ( P 0.01). Conclusion Ethanol administration can markedly led to the gene expression of TLR 4 in KCs, and TLR 4 and cytokines may play a major role in the development of alcohol induced liver injury." @default.
- W2352303229 created "2016-06-24" @default.
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- W2352303229 date "2002-01-01" @default.
- W2352303229 modified "2023-09-25" @default.
- W2352303229 title "The role of Toll-like receptor 4 in Kupffer cells and cytokines in alcohol-induced liver disease in rats" @default.
- W2352303229 hasPublicationYear "2002" @default.
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