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- W2352324109 abstract "Objective To investigate the difference between H99 biofilms and PMT4 mutant′s in the resistance against antifungal drugs.Methods Long flanking homology(LFH-)PCR was used to get the PMT4 mutant.Animal model was built by setting a catheter(with polystyrene film in lumens) into rabbit's central venous.M27A2 program was used to test MIC of planktonic cells of H99 and PMT4 mutant and of their biofilms.MTT test was used to investigate the metabolic activity of H99 biofilm cells and PMT4 mutant biofilm cells,which can show the susceptibility of H99 and PMT4 mutant cells in both in vitro model and in vivo model.Results M27A2 test(with FCZ,AmB,5-FC,ITR)showed indistinctly different MIC between wild strain and mutant or between planktonic cells and biofilm cells.But,MTT test showed that biofilm cells of mutant was much more susceptible to antifungal drugs than those of wild strain,in vitro and in vivo.Conclusion M27A2 is not appropriate for biofilm cells;PMT4 gene plays an essential role in the resistance of C.neoformans biofilm against antifungal agents.And because of the remarkable difference in properties and function of products between fungal PMT gene and its analogous gene in mammals,PMT4 gene and its products can be reasonably regarded as potential targets of new therapeutics." @default.
- W2352324109 created "2016-06-24" @default.
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- W2352324109 date "2009-01-01" @default.
- W2352324109 modified "2023-09-23" @default.
- W2352324109 title "The Role of PMT4 Gene in Resistance of Cryptococcus Neoformans Biofilms Against Antifungal Drugs" @default.
- W2352324109 hasPublicationYear "2009" @default.
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