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- W2352350518 abstract "Objective To study the effects of PM10 and PM2.5 on the secretion of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) and interleukin-8(IL-8) in the human lung fibroblast(HLF) in vitro.Methods PM10 and PM2.5 were collected during heating period.The tested cells were passage cultured HLF.Cytotoxicity of the particles was measured by MTT assay.The levels of cytokines TNF-α,IL-6 and IL-8 were determined by using radioimmunity assay.Results After 24h of treatment,PM10 and PM2.5 caused cytotoxicity to HLF,and the survival rate of the cells increased with exposure of PM10 and PM2.5 increased at low level,but decreased with exposure of PM10 and PM2.5 increased at high level.PM10 and PM2.5 increased the secretion of TNF-α,IL-6 and IL-8 in HLF.Conclusion PM10 and PM2.5 exposure my cause cytotoxicity to HLF;After 24 h of treatment,PM10 and PM2.5 can induce the early inflammatory reaction." @default.
- W2352350518 created "2016-06-24" @default.
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- W2352350518 date "2011-01-01" @default.
- W2352350518 modified "2023-09-23" @default.
- W2352350518 title "Effects of PM10 and PM2.5 on Secretion of Inflammatory Factors in Human Lung Fibroblast Cells" @default.
- W2352350518 hasPublicationYear "2011" @default.
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