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- W2352366471 abstract "OBJECTIVE To establish a HPLC method for the determination of methylene blue in plasma.METHODThe drug was extracted from plasma with C2 column by SPE method.Separation was performed on a Kromasil C18 reverse-phase analytical column(4.6 mm×250 mm,5 μm) maintained at 40 ℃.The mobile phase consisted of acetonitrile-0.3% triethylamine of aqueous solution with the pH adjusted to 2.07 by phosphoric acid(31∶69),at a flow rate of 1 mL·min-1.The UV detector used a variable wavelength that was set at 668 nm for the first 6.7 min to detect methylene blue and then switched to 254 nm until 10 min to detect phenacetin.Phenacetin was used as internal standard for the quantitation.RESULTSThe good linearity of methylene blue was obtained in the range of 8.55-855 μg·L-1.The correlation coefficient was 0.999 5 and the lower limit of quantification was 8.55 μg·L-1.The extraction recoveries were in the range of 81.08%-93.57%.The precisions of intra-batch and inter-batch were 3.93%-6.75% and 10.16%-13.36%,respectively.CONCLUSIONThe method is simple,sensitive,accurate and provides a research basis for the development of new application of methylene blue in medicine." @default.
- W2352366471 created "2016-06-24" @default.
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- W2352366471 date "2011-01-01" @default.
- W2352366471 modified "2023-09-28" @default.
- W2352366471 title "Determination of Methylene Blue in Pig Plasma Using RP-HPLC with Solid Phase Extraction" @default.
- W2352366471 hasPublicationYear "2011" @default.
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