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- W2352368534 abstract "To dissect the steroid hormone signaling pathway involved in insect cell morphological differ- entiation, we extended the application of the double- stranded RNA-mediated interference (dsRNAi) method to the epidermal IAL-PID2 cell line from Plodia interpunctella Lepidoptera. We first demon- strated that dsRNAwas capable of efficiently blocking the steroid hormone 20-hydroxyecdysone (20E) in- ducibility of proteins that belong to the nuclear receptor superfamily, including the ecdysone receptor (EcR), its partner Ultraspiracle (USP), the insect homolog of the vertebrate retinoid X receptor and the HR3 transcription factor. We then showed that inhibiting the 20E induction of EcR, USP or HR3 proteins prevented the increased synthesis of b tubulin and consequently the morphological transformation of cells. Thanks to this functional approach, we have shown, for the first time, the participation of EcR, USP and HR3 in a 20E signaling pathway that directs morphological differentiation in insect cells by regu- lating b tubulin expression." @default.
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- W2352368534 date "2007-01-01" @default.
- W2352368534 modified "2023-09-27" @default.
- W2352368534 title "Research Article Identification of steroid hormone signaling pathway in insect cell differentiation" @default.
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