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- W2352401023 abstract "Objective: To analyze the chromosome abnormalities in spontaneous abortion during the first trimester between natural and assisted reproduction technology(ART) pregnancy,and to provide some useful data for eugenics.Methods: A retrospective analysis was performed on 120 clinical spontaneous abortion cases during the first trimester following natural or ART pregnancy.Chorionic villus was successfully cultured and analyzed in 99 cases,with 64 cases of natural pregnancy group(N group) and 35 cases of ART group.Cytogenetic analysis of the chorionic villi cytogenetic status was performed in two groups.Results: ①The success culture rate was 81.9%(99 /120).②The normal karyotypes were identified in 38 cases of N group and 20 cases of ART group.The abnormal karyotypes were identified in 26 cases of N group and 15 cases of ART group.③The majority type of abnormal karyotypes was numerical abnormalities,counting for 92.6%(38 /41),34 cases of aneuploidy,counting for 82.9%,and trisomies for chromosomes were common,counting for 58.5%(24 /41).In N group,there were 2 case of tetraploid,1 case of triploids,1 case of triploids with chromosome number abnomalities in autosome,7 cases of sexual chromosome number abnormalities,13 cases of autosomal abnormality(including 2 cases of chimera),and 1 case of Robertsonian translocation.In ART group,there was 1 case of tetraploid,1 case of sexual chromosome number abnormalities,and 11 cases of autosomal abnormality(including 2 cases of chimera).④There was no significant difference in sexuality ratio of chorionic villus cell chromosome abnormality.⑤ There was no significant difference in chorionic villus cell chromosome abnormality between the patients whose age was equal or over 35 years old and below 35 years old.⑥In N group,the ratio of chorionic villus cell chromosome abnormality was significantly higher in the patient with history of twice or over twice spontaneous abortion than the patient with less than twice spontaneous abortion.Conclusion: Spontaneous abortion during the first trimester is closely related with embryo chromosome abnormalities.Aneuploidy is the major factor affecting embryonic development in spontaneous abortions during the first trimester.Compared with natural pregnancy,ART doesn't increase the rate of chorionic villus cell chromosome abnormality in spontaneous abortion during the first trimester." @default.
- W2352401023 created "2016-06-24" @default.
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- W2352401023 date "2013-01-01" @default.
- W2352401023 modified "2023-09-23" @default.
- W2352401023 title "The chorionic villus cell analysis on chromosomal karyotype in spontaneous abortion during the first trimester between natural and assisted reproductive technology pregnancy" @default.
- W2352401023 hasPublicationYear "2013" @default.
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