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- W2352408857 abstract "Objective To clarify the role of a cell cycle regulator, cyclin D1 and CDK6 in patients with gastric carcinoma. Method Tissue samples from 48 patients with gastric carcinoma were included in the current study. Expression levels of cyclin Dl and CDK6 in samples of normal mucosa and tumor tissue were analyzed by Western blot. Result Overexpression of cyclin Dl and CDK6 protein were demonstrated in 58% and 69% of gastric cancer tissues, respectively. Several clinicopathologic parameters, including depth of tumor invasion, pathologic lymph node status and tumor stage ( P0.05) were correlated with the overexpression of cyclin D1. Elevated expression of CDK6 correlated with poor histological grade, lymph node involvement and tumor stage ( P0.05). No positive linear correlation was noted between the expression of cyclin D1 and CDK6. Multivariate analysis showed overexpression of CDK6 was correlated with a poor prognosis in patients with gastric cancer. In contrast, cyclin D1 expression was not an independent prognostic factor. Conclusion These findings suggest that cyclin D1 and CDK6 may play important role in the development and progression of gastric cancer. CDK6 expression, but not cyclin D1 expression may indicate a poor prognosis for patients with gastric cancer." @default.
- W2352408857 created "2016-06-24" @default.
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- W2352408857 date "2005-01-01" @default.
- W2352408857 modified "2023-09-23" @default.
- W2352408857 title "Prognostic value of cyclin D1 and CDK6 expression in patients with gastric carcinoma" @default.
- W2352408857 hasPublicationYear "2005" @default.
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