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- W2352410347 abstract "Objective To determine autocrine expression of bladder cancer cells and explore the mechanism of hydroxycamptothecin (HPT)on autocrine expression. Methods IL 6,IL 6 receptors,IGF 1,IGF 2,IGF 1 receptors mRNAs of T24 bladder cancer cells in the condition of serum free culture were investigated by semiquantitative RT PCR after bladder cancer cells treated by HPT at the concentrations of 0.005, 0.010, 0.020 mg/L respectively. Results Compared to the HPT untreated bladder cancer cells group,the intrinsic mRNA expression of IGF 1,IGF 2,IGF 1 receptors,IL 6,IL 6 receptors was reduced approximately by 44.8%,59.7%,39.3%,51.5% and 46.2% respectively after treatment of 0.010 mg/L HPT( P 0.05). Conclusion The down regulation of HPT on autocrine expression of bladder cancer may contribute to its mechanisms for antitumor activity." @default.
- W2352410347 created "2016-06-24" @default.
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- W2352410347 date "2001-01-01" @default.
- W2352410347 modified "2023-09-23" @default.
- W2352410347 title "Effect of 10 hydroxycamptothecim on autocrine expression of T24 urinary bladder cancer cells" @default.
- W2352410347 hasPublicationYear "2001" @default.
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