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- W2352419400 abstract "Objective To explore the relationship between phosphotylinosital 3 kinase/protein kinase B 1 / mammalian target of rapamycin( PI3 K / Akt1 / m TOR) pathway and epidermal growth factor receptor( EGFR) gene,and lay the foundation for the related mechanisms of PI3 K / Akt1 / m TOR pathway in EGFR-tyrosine kinase inhibitor( TKI) resistance. Methods Detecting the mRNA expressions of PIK3 CA,Akt1,m TOR and EGFR in 135 non-small cell lung cancer( NSCLC) patients without any treatment,and the correlation was analyzed. Results EGFR,Akt1 and m TOR gene expressions are correlated with each other( r = 0. 342,0. 320 and 0. 281; P 0. 01),other than PIK3 CA gene. Conclusion EGFR gene expression is related to Akt1 and m TOR other than PIK3 CA,which indicate that EGFR gene may activate Akt1 and its downstream directly,not through PI3 K." @default.
- W2352419400 created "2016-06-24" @default.
- W2352419400 creator A5071375151 @default.
- W2352419400 date "2014-01-01" @default.
- W2352419400 modified "2023-09-23" @default.
- W2352419400 title "mRNA expression of epidermal growth factor receptor,phosphotylinosital 3 kinase,protein kinase B1,mammalian target of rapamycin and their clinical significance in non-small cell lung cancer tissue" @default.
- W2352419400 hasPublicationYear "2014" @default.
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