Matches in SemOpenAlex for { <https://semopenalex.org/work/W2352424396> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2352424396 abstract "Objective To measure blood and tissue fluid concentrations of levofloxacin(LVFX) in rabbits and calculate the drug and pharmacokinetic parameters after intravenous injection,and then provide the basis for the transition of common pathogens such as Pseudomonas aeruginosa in vitro studies to in vivo.Methods The rabbit cage models were established,and then rabbit blood and tissue fluid concentrations of LVFX at different times were measured by high performance liquid chromatography(HPLC).The pharmacokinetic parameters were calculated.Results After 10 mg/kg LVFX was intravenously injected in rabbits,the peak concentration(Cmax) of LVFX in blood and tissue fluid was(8.27±0.9) and(2.48 ±0.3)mg/L;the half-life(T1/ 2β) of various concentrations in blood and tissue fluid was(1.06±0.1) and(3.63±1.3)h;the apparent volume of distribution was(1.55±0.3)and(4.89±2.1)L/kg.Conclusion LVFX shows good penetration when administered by intravenous injection in the tissue fluid.Both the long half-life of LVFX and small fluctuation of drug concentration could be helpful to maintain therapeutic levels in tissue fluid." @default.
- W2352424396 created "2016-06-24" @default.
- W2352424396 creator A5088688923 @default.
- W2352424396 date "2010-01-01" @default.
- W2352424396 modified "2023-09-24" @default.
- W2352424396 title "Pharmacokinetics of levofloxacin in rabbit blood and tissue fluid after intravenous injection" @default.
- W2352424396 hasPublicationYear "2010" @default.
- W2352424396 type Work @default.
- W2352424396 sameAs 2352424396 @default.
- W2352424396 citedByCount "0" @default.
- W2352424396 crossrefType "journal-article" @default.
- W2352424396 hasAuthorship W2352424396A5088688923 @default.
- W2352424396 hasConcept C112705442 @default.
- W2352424396 hasConcept C127413603 @default.
- W2352424396 hasConcept C142724271 @default.
- W2352424396 hasConcept C150903083 @default.
- W2352424396 hasConcept C179998833 @default.
- W2352424396 hasConcept C185592680 @default.
- W2352424396 hasConcept C207001950 @default.
- W2352424396 hasConcept C22979827 @default.
- W2352424396 hasConcept C2776735168 @default.
- W2352424396 hasConcept C2779822359 @default.
- W2352424396 hasConcept C2781276175 @default.
- W2352424396 hasConcept C2908754555 @default.
- W2352424396 hasConcept C42475967 @default.
- W2352424396 hasConcept C43617362 @default.
- W2352424396 hasConcept C50156730 @default.
- W2352424396 hasConcept C501593827 @default.
- W2352424396 hasConcept C55493867 @default.
- W2352424396 hasConcept C71924100 @default.
- W2352424396 hasConcept C80107235 @default.
- W2352424396 hasConcept C86803240 @default.
- W2352424396 hasConcept C98274493 @default.
- W2352424396 hasConceptScore W2352424396C112705442 @default.
- W2352424396 hasConceptScore W2352424396C127413603 @default.
- W2352424396 hasConceptScore W2352424396C142724271 @default.
- W2352424396 hasConceptScore W2352424396C150903083 @default.
- W2352424396 hasConceptScore W2352424396C179998833 @default.
- W2352424396 hasConceptScore W2352424396C185592680 @default.
- W2352424396 hasConceptScore W2352424396C207001950 @default.
- W2352424396 hasConceptScore W2352424396C22979827 @default.
- W2352424396 hasConceptScore W2352424396C2776735168 @default.
- W2352424396 hasConceptScore W2352424396C2779822359 @default.
- W2352424396 hasConceptScore W2352424396C2781276175 @default.
- W2352424396 hasConceptScore W2352424396C2908754555 @default.
- W2352424396 hasConceptScore W2352424396C42475967 @default.
- W2352424396 hasConceptScore W2352424396C43617362 @default.
- W2352424396 hasConceptScore W2352424396C50156730 @default.
- W2352424396 hasConceptScore W2352424396C501593827 @default.
- W2352424396 hasConceptScore W2352424396C55493867 @default.
- W2352424396 hasConceptScore W2352424396C71924100 @default.
- W2352424396 hasConceptScore W2352424396C80107235 @default.
- W2352424396 hasConceptScore W2352424396C86803240 @default.
- W2352424396 hasConceptScore W2352424396C98274493 @default.
- W2352424396 hasLocation W23524243961 @default.
- W2352424396 hasOpenAccess W2352424396 @default.
- W2352424396 hasPrimaryLocation W23524243961 @default.
- W2352424396 hasRelatedWork W118390438 @default.
- W2352424396 hasRelatedWork W2007102540 @default.
- W2352424396 hasRelatedWork W2037883751 @default.
- W2352424396 hasRelatedWork W2042505947 @default.
- W2352424396 hasRelatedWork W2085265375 @default.
- W2352424396 hasRelatedWork W2094219937 @default.
- W2352424396 hasRelatedWork W2125210221 @default.
- W2352424396 hasRelatedWork W2256490948 @default.
- W2352424396 hasRelatedWork W2349055232 @default.
- W2352424396 hasRelatedWork W2349808322 @default.
- W2352424396 hasRelatedWork W2351351947 @default.
- W2352424396 hasRelatedWork W2357871852 @default.
- W2352424396 hasRelatedWork W2367320434 @default.
- W2352424396 hasRelatedWork W2368541339 @default.
- W2352424396 hasRelatedWork W2373497651 @default.
- W2352424396 hasRelatedWork W2387419976 @default.
- W2352424396 hasRelatedWork W2389141822 @default.
- W2352424396 hasRelatedWork W2390849530 @default.
- W2352424396 hasRelatedWork W2393788733 @default.
- W2352424396 hasRelatedWork W2189312125 @default.
- W2352424396 isParatext "false" @default.
- W2352424396 isRetracted "false" @default.
- W2352424396 magId "2352424396" @default.
- W2352424396 workType "article" @default.