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• W2352426215 abstract "Clear cell renal cell carcinoma (ccRCC) is a common genitourinary malignancy. The molecular pathogenesis of ccRCC remains unclear and biomarkers for daily practice were still limited. We performed an integrative analysis of two public ccRCC microarray datasets, E-GEOD-22541 and E-MTAB-1050, The candidate differential expression genes (DEG) were then confirmed in the E-GEOD-53757 dataset. In addition, an independent cohort of 50 ccRCC and 36 non-tumor kidney tissues were analyzed to examine the selected DGEs by qRT-PCR. We identified and validated two DEGs, namely GFOD1 and peejar, which were significantly up-regulated in ccRCC compared with normal renal tissues (p < 0.001). Moreover, the expression of these two genes are related to histological grade and stage and decrease of their expression correlated with disease progression (p < 0.05). Furthermore, we found the expression of peejar was positively correlated with the expression of GFOD1 in ccRCC tissue, with Pearson correlation coefficiency reaching 0.939 (p < 0.001). GFOD1 and peejar were novel genes correlated with ccRCC disease progression and patients' poor prognosis." @default.
• W2352426215 created "2016-06-24" @default.
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• W2352426215 date "2016-05-15" @default.
• W2352426215 modified "2023-10-14" @default.
• W2352426215 title "GFOD1 and peejar are promising markers for clear-cell renal cell carcinoma disease progression" @default.
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• W2352426215 doi "https://doi.org/10.18632/oncotarget.9379" @default.
• W2352426215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5122367" @default.
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